Dental Arch Relationships Following BMP-2 Versus Non-BMP-2 Alveolar Cleft Repairs
Jeremy A. Goss, BA1, Lawrence A. Rudolf, BS, BA1, Richard O'Brien, DDS2, Margie S. Hunter, BS1, Eric S. Armbrecht, PhD3, Ross E. Long, Jr., DMD, MS, PhD4, Alexander Y. Lin, MD1.
1Saint Louis University School of Medicine, St. Louis, MO, USA, 2Center for Advanced Dental Education - Saint Louis University, St. Louis, MO, USA, 3Saint Louis University Center for Outcomes Research, St. Louis, MO, USA, 4Lancaster Cleft Palate Clinic, Lancaster, PA, USA.
A former surgeon at our institution frequently used bone morphogenetic protein-2 (BMP-2) instead of autograft for alveolar bone reconstruction (ABR). Goslon Yardstick scores and maxillary intermolar distances were used to compare dental arch relationships between patients who underwent BMP-2 (BY) versus non-BMP-2 ABR (BN).
Four raters evaluated all pre-orthodontic treatment dental casts available using the Goslon Yardstick scores (GS) and intermolar distances (IMD) from the mesial-buccal cusps of the maxillary first molars. Data were averaged and analyzed by BMP-2 exposure history, age at alveolar surgery, and time between cast and surgery. A general linear model was used for analysis.
In patients for whom BMP-2 was used for alveolar cleft repairs, postoperative dental arch relationships do not appear to be significantly different from non-BMP-2 alveolar surgeries as evidenced by averaged Goslon Yardstick scores and maxillary intermolar distances.
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